CBR-partnered clinical trials

Paving the way for further treatments

CBR is advancing potential newborn stem cell uses by partnering with leading research institutions to establish FDA-regulated clinical trials, exploring the use of a child’s own stem cells for conditions that currently have no cure.

Cord blood stem cells are currently being evaluated as potential treatments for:

What is acquired sensorineural hearing loss?

Sensorineural hearing loss (SNHL) is a specific type of hearing loss that involves damage to, or dysfunction of, the inner ear (as opposed to other structures of the ear). Acquired SNHL can happen as the result of premature birth, infections, or exposure to loud noise or to certain drugs, resulting in irreversible damage to the fragile hair cells (cilia) in the inner ear.105

15%

Children who have low or high frequency hearing loss.103

50% - 70%

Children whose SNHL has no genetic component (acquired).104

40%

Young adults with hearing loss who experience a limitation in daily functioning.103

45,000

Infants born in the U.S. from 2005-2014 with hearing loss.103

The potential role of newborn stem cells

Cord blood stem cells may have unique advantages:

Targeted therapy

Unlike other hearing loss treatments, early laboratory studies have shown that cord blood stem cells appear to address the underlying cause of hearing loss directly by helping to regenerate delicate structures within the inner ear.106

Self-repair

In laboratory studies, newborn stem cells have demonstrated the ability to hone in on the site of damage. They may also have the potential to spur the repair mechanism at that site.106

Safe and accessible

Cord blood can be easily collected at the time of birth and stored for potential future use by the newborn donor or close family member.

What is autism?

Autism, or Autism Spectrum Disorder (ASD), is a complex disorder with a wide range of signs and symptoms. No two children with autism are exactly alike, however, they may share commonalities such as difficulties with language and social interactions. Scientists are hoping to find new treatments that "calm" this overactive immune response to help protect the developing brain in young children with autism.

1 in 68

1 in 68 children have autism spectrum disorder (ASD).93

4.5x

ASD is about 4.5 times more common among boys (1 in 42) than among girls (1 in 189).93

All backgrounds

ASD occurs in all racial, ethnic, and socioeconomic groups.93

2-6 years old

Most children are diagnosed with autism between this age range.93

The potential role of newborn stem cells

Cord blood stem cells may have unique advantages:

Anti-inflammatory properties

Early research has shown that cells found in cord blood have the ability to regulate inflammation and migrate to the site of neurologic injury.96,97

Bystander effect

The working theory is that the infused cells secrete factors that promote the body’s own repair mechanism in the surrounding tissue(s) via paracrine signaling, or what is commonly referred to as the bystander effect.98

Safe and accessible

Cord blood can be easily collected at the time of birth and stored for potential future use by the newborn donor or close family member.

What is cerebral palsy?

Cerebral palsy is caused by a brain injury or lack of oxygen in the brain before or during birth or in the first few years of life. It can impair movement, learning, hearing, vision, and cognitive skills. Cerebral means having to do with the brain. Palsy means weakness or problems with using the muscles. CP is the most common motor disability in childhood.

1 in 323

According to the Centers for Disease Control and Prevention, it is estimated that roughly 1 in every 323 children in the United States has been diagnosed with cerebral palsy.

85%-95%

The majority of CP (85%–90%) is congenital. It is thought to be present from birth, although in many cases, the specific cause is not known.

12-18 months

The symptoms of Cerebral palsy, except in its mildest forms, can be evident in the first 12-18 months.

All backgrounds

Cerebral palsy occurs in all racial, ethnic, and socioeconomic groups.

The potential role of newborn stem cells

Cord blood stem cells may have unique advantages:

Anti-inflammatory properties

Early research has shown that cells found in cord blood have the ability to regulate inflammation and migrate to the site of neurologic injury.

Bystander effect

Previous pre-clinical research has shown that umbilical cord blood (CB) contains effector cells that can suppress inflammation and alter synapse connectivity via paracrine signaling. Early trials have reported results suggesting cord blood infusion may have the potential to improve gross and fine motor function and increase whole brain connectivity.

Safe and accessible

Cord blood can be easily collected at the time of birth and stored for potential future use by the newborn donor or close family member.

Leading research institutions

Hear from those that know us best.

"For all the parents out there considering preserving their newborn stem cells, I can't stress how important it is… we're so happy we did this."

Sarah Huber, Grace's mom

Grace was born with a condition called sensorineural hearing loss. Because her parents preserved her newborn stem cells with CBR, she was connected to a clinical trial through the Family Health Registry.

Preserve with CBR

Take advantage of this once-in-a lifetime opportunity.